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Non-covalent inhibitors of AmpC beta-lactamase
Non-covalent inhibitors of AmpC beta-lactamase
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机译:AmpCβ-内酰胺酶的非共价抑制剂
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摘要
-lactamases are the most widespread resistance mechanism to -lactam antibiotics, such as penicillins and cephalosporins. In response to these enzymes, inhibitors have been introduced. Unfortunately, these inhibitors are also -lactams, and resistance to them has developed rapidly. Consequently, the present invention provides a novel structure-based approach to inhibitors of these enzymes.
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