Method of immobilising molecules and particles on a hydrophobic polymer surface wherein mucin is used

摘要

The present invention generally relates to a method of immobilising molecules or particles on the surface of hydrophobic polymeric materials, wherein said immobilisation is mediated by a mucin layer adsorbed to said surface. More particularly the invention relates to such a method, wherein the polymeric material is a biomaterial for in vivo applications. The present invention also relates to a hydrophobic polymeric substrate provided with a mucin layer having selected molecules and/or particles immobilised thereto, obtainable by means of the method, and a biocompatible highly specific binding system comprising a mucin and a lectin or a functional fragment of a lectin, which system can be used in the method.