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Methods of characterizing molecular interaction sites on proteins
Methods of characterizing molecular interaction sites on proteins
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机译:表征蛋白质分子相互作用位点的方法
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摘要
The present invention is directed to methods of characterizing molecular interaction sites on a biological target molecule. The methods involve contacting a polypeptide with a library of ligand candidates each of which is capable of tethering to the polypeptide at a site of interest, and analyzing the physicochemical properties of the ligand candidates tethering to the polypeptide. The methods herein are useful for discovery of and development of small molecule drugs.
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