Expression of keratin genes 8 and 18 for treating tumours,in particular a mammary carcinoma

摘要

The invention is concerned with a means for the therapy of malignant diseases, in particular for the prevention or inhibition of metastases of solid tumours expressing HER2. The means in keeping with this invention is characterized by the fact that it favours the expression of the Keratin genes 8 and 18 (K8, K18) in tumour cells. The K18 gene is preferred for the gene therapeutic treatment and it is preferential for the HER2-mediated in vivo transfection with a liposomal capsule equipped with antibodies against the HER2 receptor. The subject of the invention is thus the use of the K8 and K18 genes for the therapy of solid tumours, in particular for breast cancer. Areas of application for the invention are in medicine and the pharmaceutical industry.