N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists

摘要

The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises administering to that subject a therapeutically effective amount of a compound of formula I: chemistry chemdraw filechemistry mol file;wherein, generally, ;Q is chemistry chemdraw filechemistry mol file;R¹ is benzyl, phenyl, thiophene or imidazolyl optionally substituted with C_1-4alkyl or halogen, such as methyl, fluorine or bromine; ;R² is hydrogen or C_1-4alkyl such as methyl; ;R³ is phenyl; ;R⁴ is hydrogen; ;R⁵ is hydrogen or C_1-6alkylcarbonyl such as methylcarbonyl; ;X is —SO₂— or —C(O)N(R²)SO₂— where R² is preferably hydrogen; ;Y is a bond, CH₂ or Z¹ where Z¹ is —N(R^f)— in which R^f is C_1-6alkylcarbonyl such as ethylcarbonyl; and ;R⁶ is phenyl, pyrazolyl, pyridyl, pyrimidinyl or benzimidazolonyl optionally substituted with one or two groups chosen from C_1-6alkyl and benzyl, such as methyl, ethyl and benzyl; ;or a pharmaceutically acceptable salt thereof.