- aryl oxime Piperazines Compounds, Pharmaceutical composition, the use of such compounds for the manufacture of Drugs useful as CCR5 antagonists and a Team

摘要

1. Aril oxma piperazines compound, including Omer, stereoisomer, tumbler, tumbler and derivatives of the compound, as well as pharmaceutically acceptable salts or solutions of the compound or derivatives, with the General Pharmaceutical structure (1),Where x is selected from groups h, F, Cl, Br, I, CF3, cf3o, CN, ch3so2,And cf3so2 -;R1 is h, a C1-6 fluoro tar, C1-6 tar, rectal tar, or branched chain tar with c3-7 cyclopentadiene, such as cyclopentamethyl,-C1-6 SCCPs, C1-6, or C16, C16, or C16, or c15-6, or C16 (b) a. Hetero compounds of 6 members substituted by R4, R5 and R6; hetero oxides of 6 members substituted by R4, R5 and R6; hetero compounds of 5 members substituted by R7 and R8; Northwest fluorine; fluorodiphenyl; and other formulas (2);Or other formula (3);In which R4 and R5 may be the same or different, and are independently selected from a group containing C1-6, halogen, nr12r13, oh-cf3, OCH3, o-acilo, ocf3 and - Si (CH3) 3, R6 as R4, hydrogen, phenyl, NO2, CN, ch2f, chf2, CHO, ch = nor12, piridio, n (R12) and conr13r14, -Nhconh (chlorine - (C1-6) asphalt,-Nhonh (c3-10) cyclopentadiene (C1-6) tar,Nhco (C1-6) asphalt, - nhcof3, - nhso2n ((C1-6) asphalt) 2, - nhso2 (C1-6) asphalt, - n (so2cf3),-NHCO2 (C1-6) alkyl, C3-10 cycloalkyl, -SR15, -SOR15, SO2R15, -SO2NH (C1-6) alkyl, -OSO2 (C1-6) alkyl, -OSO2CF3, hydroxy (C1-6) alkyl , -CONR12R13, -CON (CH2CH2-O-CH3) 2, -OCONH (C1-6) alkyl, -CO2R2, -Si (CH3) 3 or -B (OC (CH3) 2);R7 is the tar of C1-6, NH2 or r9-phenyl; R9 is one to three substitutes, which can be the same or different, and is a group independent of hydrogen, C1-6, CF3, co2r12, CN, alcox C1-6 and halogenated substances; R10 and R11 may be the same or different and selected independently from the group consisting of C1-6 hydrogen and tar, or R10 and R11 together are a c2-5 tar group connected with carbon atoms to form a spiral of 3 to 6 carbon atoms; R12, R13 and R14 may be the same or different, separated from group H and C1-6 tar; R15 is C1-6 tar or phenyl;Pharmaceutical compounds containing one or more compounds used in the manufacture of drugs for the treatment, prevention and improvement of one or more diseases associated with CCR5 receivers, and devices containing a single package, A composite agent for the treatment of human immunodeficiency virus, including a drug ingredient in a container, which contains an effective amount of CCR5 antagonists, an acceptable drug carrier, and a separate package,1. One or more pharmaceutical ingredients, including an effective number of antiviral agents or other effective preparations for the treatment of human immunodeficiency virus with drug acceptable carriers.