Use of a chemotherapeutic agent for the manufacture of a Medicament for the sensitization of neoplastic cells resistant to chemotherapeutic agents with Reovirus

摘要

Use of a chemotherapeutic Agent, which comprises (a) an effective amount of a reovirus; and (b) an effective amount of the chemotherapeutic Agent to the cell, which is for the manufacture of a Medicament for the sensitization of a cancer cell.Claim 6: the method of claim 1, in which the chemotherapeutic Agent selected from the group consisting mitomicin C, 5-fluorouracil, cyclophosphamide, methotrexate, Hydroxyurea, dacarbazine, anthracyclines, Mitoxantrone, etoposide, cisplatin, Taxol, TAXOTERE, tamoxif In, anti estrogens and interferons.Claim 1: the method of claim 10, in which the reovirus Serotype 3 is a reovirus Strain Dearing.Claim 12: a method for treating a subject with a proliferative Disorder, in which the subject comprises neoplastic cells that are Refractory to a chemotherapeutic Agent,Comprising: (a) administering to the subject an effective amount of reovirus in conditions that result in an infection of neoplastic cells by reovirus; and (b) administering an effective amount of the chemotherapeutic Agent to that subject. The Method of claim 19: 12 the claim, which is a solid tumor proliferative disorder.The Method of claim claim 20: 19, in which the solid tumor is selected from the group consisting of Lung Cancer, prostate cancer, colorectal cancer, Thyroid cancer, renal cancer, adrenal cancer, liver cancer, pancreatic cancer, Breast Cancer and C Cancer of the Central and Peripheral nervous system.