Compound of substituted pyrrole Derivative, Pharmaceutical Composition and its use in the manufacture of a Medicament for inhibiting farnesyltransferase

摘要

1. A compound made of a flame retardant or an acceptable salt for therapeutic use substituted by formula (1), wherein e is an aromatic or non aromatic carbon ring consisting of 5, 6 or 7 members, of which zero to 3 carbon atoms are replaced by nitrogen; F and G are independent of C and N, but when f and G are n, others are C; L1 and L2 are independently selected from the group consisting of C2 tar link, C2 tar reservoir, O, nr9, C (o).S S (O) SO2 SO2NR9 NR9SO2 C (O) NR9 NR9C (O)R1 is selected from a group consisting of arilo, arilalquilo, heterocyclic and (non cyclic) aspha R2 is selected from a group consisting of hydrogen, alcoxi, hydrocarbon, aminobenzene, aminobenzene, cyanogen, cyanopropyl, cyclopropene, cyclopentadienyl, cyclopentadienyl, halogenation and heterocyclic asphalt. 1.3.1.1.1. Tar, hydroxyl and hydroxide; R3 was selected from the group consisting of arilo, heterocycle and cyclopentyl; r4-6 was selected from the group 9C (o) of hydrogen;Hydroxilo, hydroxilo, hydroxilo, hydro, hidroxilo, nilqui 1. Nitrotoluene, oxo and uncle (oxo);R7 was selected from the group consisting of hydrogen, tar, arilo, cyclomethyllukilo, cyclomethylkaladiene, heterocyclic asphalt, isopropyoxyla and trialquillo; R9 was selected from the group consisting of hydrogen, oxygen tar, tar, amido alekillo, aminokillo, arilalquilo, cyclomethyllu, cyclomethyllu, cyclomethylkalquillo and carboxalquilo, Heterosexual (heterosexual)1. Each R12 shall be independent of the group consisting of hydrogen, oxygen, hydrocarbon, amino group, halogen and oxyhydrogen; m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; P is 0, 1, 2, 3 or 4; q is 0, 1, 2, 3 or 4. Also disclosed are the inhibitory components and the use of these compounds for the production of drugs to inhibit the patient's f-transferase.