8 pirido 2,3 pyrimidine 7 ones 2,4,8 - trisustituidas, Pharmaceutical compositions that include, use of these compounds in the manufacture of Drugs, Intermediates useful in the preparation of such Compounds, and processes for preparing Said compounds

摘要

8 pirido [2.3D] pyrimidine 7 ones 2,4,8 - trisustituidas formula (1) or (2) or pharmaceutically acceptable salts thereof wherein R1 is an optionally substituted aryl or heteroaryl Ring optionally substituted alkyl; R2 is Hydrogen, C1 - C3 - 7 10, cycloalkyl alkyl, cycloalkyl C3 - 7, Ari The alkyl aryl, heteroaryl heteroaryl - 10 C1, C1 -, alkyl - 10A Functional group or a Heterocyclic alkyl Functional Group heterociclil C1 - 10, All Functional groups which are optionally substituted, or R2 is the functional Group cr10r20 x1) QC (A1), (A2), (A3)Or C (A1), (A2), (A3); A1 is a C1 - 10 alkyl optionally substituted alkyl; A2 is an optionally substituted C1 - 10; A3 is Hydrogen or alkyl of C1 - 10 is an optionally substituted alkyl; R3 is a C1 - C3 - 7 10, cycloalkyl alkyl, cycloalkyl C3 - 7 - c1-4 alkyl, aryl, aryl and heteroaryl, C1 - 10 Roaril C1 - 10 - alkyl Functional Group, a Heterocyclic alkyl or heterociclil C1 - 10Functional groups which are optionally substituted; R4 and R14 are each independently selected from Hydrogen, alkyl, optionally substituted cycloalkyl C1 - C3 - 4, 7 - 7 pp. ISBN cycloalkyl optionally substituted alkyl, optionally substituted aryl c1-4, c1-4 alkyl or aryl - option At present, replaced, or R9 and R14, along with the nitrogen Atom to which they are UnitedForm an optionally substituted Heterocyclic Ring of 4 to 7 Elements, optionally an additional Rings containing heteroatom selected from Oxygen, Sulfur or NR9 R6 is Hydrogen, alkyl, cycloalkyl C1 - C3 - 10, 7, heterociclilo, heterociclil C1 - aryl alkyl, aryl, alkyl - C1 10, or heteroaryl heteroaryl alkyl C1 - 10In each of these Functional groups can be optionally replaced; R9 is Hydrogen, C (Z) R6 C1 - 10 or alkyl aryl optionally substituted, optionally substituted aryl or alkyl, optionally substituted C1 - 4; R10 and R20 were selected independently between Hydrogen or alkyl C1 - 4; X is R2, OR2, S (MR2), (CH2) NN (R10) (MR2), S (CH2) NN (R10) C (o) - (CH2) nnr4r14,Or (CH2) NN (R2) 2; x1 is N (R10), or s (o) M or cr10r20; n is 0 or an integer number that has a value of 1 to 10; M is 0 or an integer number that has a value of 1 is 0 or 2, Q whole number that Has a value of 1 to 10; Z is Oxygen or Sulfur Compounds are useful in therapy, such as inhibidore S of the CSBP / p38 Kinase.Also disclosed is the use of said compounds in the manufacture of Medicines, Pharmaceutical compositions comprising such Compounds, processes for preparing such compounds and Intermediates useful in the preparation of such compounds.