Compounds derived from 2 - (4 - il - 6.7 - dihydro - 5h pyrrolo 2,3-d pyrimidine or 2 - (4 - pirido IL - 5,6,7,8-tetrahydro - 2,3-d pyrimidine,PI3K Inhibitors, Pharmaceutical composition comprising these Compounds, and the use of the compounds in the preparation of Drugs useful in the treatment of cancer.

摘要

A drug is provided that is useful as a preventive or therapeutic for cancer as a result of having superior PI3K inhibitory effects as well as superior stability in the body and water-solubility. A compound, or pharmaceutically acceptable salt thereof, represented by formula (I): [wherein, X represents a single bond, etc.; Y represents a single bond, etc. (provided that X and Y are not simultaneously single bonds); Z represents a hydrogen atom, etc.; m represents an integer of 1 or 2; and R 1 represents a cyclic substituent].