Process for preparing compounds of metanodibenzosuberano 10,11 - and pharmaceutically acceptable salts of the compounds, method for Preparing information intermediaries in this procedure; triclorhidratos crystalline (2R) - anti - 5 - {3 - 4 - (1 - difluorometanodibenzo - 5 - 1 - il) piperacin

摘要

The preparation procedure of 10.11-dibenzofuran derivatives (alternative substitutes) is described and the requirements are put forward. The present document also provides an intermediate document for this procedure. The procedure includes the preparation of formula compound (1), where a is - ch2-ch2 -.-CH2-CHRA-CH2-CH2-CHRA-CH2-CH2R1 is oh; R1 is h, F, CL or br; R2 is h, F, CL or br; R3 is isobutylene or phenyl, respectively, substituted by F, Cl, Br, CF3, CN, NO2 or ochf2; or pharmaceutically acceptable salts, whose characteristics include (a) reacting a formula compound (2) with a nuclear power source to form a nuclide source. 1. Formula compound (3);(b) Reacting a formula compound (3) with pyridine to provide a formula compound (4);(c) Reducing formula compound (4) to provide a formula compound (5);(d) A formula compound (5) reacts with: (1) formula (6) of an epoxy compound, wherein R3 is the defined integer and N is the integer 1 or 2; or (2) formula (7) of a halogenated compound: X1 - (CH2) m-o-r3, wherein R3 is previously defined, X1 is halogenated compound and M is 2, 3 or 4; And (E) optionally producing a pharmaceutically acceptable salt from a formula compound (6) or (7).