首页> 外国专利> Process for preparing compounds of 2 - phenyl - 3 - phenoxy or phenylthio - benzothiophene and pharmaceutically acceptable salts thereof,Composite Application Exclusive intermediaries in the procedure and Method for preparing the compounds mentioned intermediaries

Process for preparing compounds of 2 - phenyl - 3 - phenoxy or phenylthio - benzothiophene and pharmaceutically acceptable salts thereof,Composite Application Exclusive intermediaries in the procedure and Method for preparing the compounds mentioned intermediaries

机译:制备2-苯基-3-苯氧基或苯硫基-苯并噻吩化合物及其药学上可接受的盐的方法,复合应用方法中专有的中间体和制备所述化合物的方法

摘要

The invention provides an effective formula (I) compound, wherein: R1 es-h-oh-o (C1-C4 asphalt),-Occ6h5-oco (C1-C6, o-oso2 (C2-C6) tar);R2 is - H-O-O (C1-C4 tar)-Occ6h5-oco (C1-C6 tar),-Sososo2 (C2-C6 tar) or halo; R3 es1-pirolidinilo, 1-pirolidilo, methyl-1-pirolidilo, dimethil-1-pirolidilo, 4-moropolino, dimethylamine, dietitiamine, diisopropilamino o 1-hexamethylenemino; n is 2-3; Z es-o-o-s; or acceptable salt. In addition, the pharmaceutical component of demormula compound (I) is also provided.
机译:本发明提供了一种有效的式(I)化合物,其中:R 1 es-h-oh-o(C1-C4沥青),-Occ6h5-oco(C1-C6,o-oso2(C2-C6)焦油); R2为-HOO(C1-C4焦油)-Occ6h5-oco(C1-C6焦油),-Sososo2(C2-C6焦油)或卤素; R 3 es1-吡咯烷酮,1-吡咯烷酮,甲基-1-吡咯烷酮,二甲基-1-吡咯烷酮,4-吗啉代,二甲胺,二乙胺,二异丙胺基氨基或1-六亚甲基氨基; n是2-3; Z es-o-s或可接受的盐。另外,还提供了脱皮化合物(I)的药物成分。

著录项

  • 公开/公告号AR003930A1

    专利类型

  • 公开/公告日1998-09-30

    原文格式PDF

  • 申请/专利权人 ELI LILLY AND COMPANY.;

    申请/专利号AR1996P101537

  • 发明设计人

    申请日1996-02-27

  • 分类号C07D333/64;A61K31/38;A61K31/381;A61K31/4025;A61K31/445;A61K31/4535;A61K31/55;A61K31/565;A61K31/57;A61P5;A61P13/02;A61P15;A61P15/12;A61P19/10;A61P43;C07D;C07D333/56;C07D333/62;C07D409/12;C07D413/12;

  • 国家 AR

  • 入库时间 2022-08-22 02:58:47

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