compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt thereof, methods for producing an inhibitory effect of hdac and cell cycle (anti-cell proliferation) and for treating cancer in an animal and a process for preparing a compound or a pharmaceutically acceptable salt thereof

摘要

B COMIPOST OR PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT, METHODS TO PRODUCE AN IMBITORY EFFECT OF THE CELLULAR CELL CELLULAR CELL CELLULAR CELL CELL IN A HOT BLOOD ANIMAL AND A PROCESS FOR PREPARING A COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME D The invention relates to benzamide compounds of formula (1), wherein R 4 is an attached pyrazole ring C 1 which is optionally substituted by one or more groups selected from C 1-4 alkyl, C 3-4 cycloalkyl, C 1-4 alkoxy and C 3-4 cycloalkoxy; or in the form of a pharmaceutically acceptable salt or prodrug thereof. The invention also relates to processes for the preparation of such compounds, to pharmaceutical compositions containing them for use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions which are sensitive to histone deacetylase (UDAC) inhibition.