Use of Derivatives of N - (indolcarbonil piperazine) for the preparation of a Medicament for the treatment of Obesity, the subtypes of anxiety, Schizophrenia subtypes and the types of Dementia for the treatment of various Origins and additional Treatment with neurole

摘要

Describes the use of Derivatives of N - (indolcarbonil) piperazine of the formula (1), wherein: R1 represents a radical phenyl or naphthyl substituted or non substituted with R2 or R3 and / or het1; R2 and R3 represents, individually and independently of each other, or, Oh, Hal, or CN, R4 and R5 represents N, individually and independently of each other, h, CN, acyl, Hal,, or, Oh, CONH2,Conha or cona2; R4 and R5, together, represent alquileno c3-5 unsaturated Heterocyclic System; het1 represents a monocyclic or bicyclic,, which is not replaced or monosustituido or alkylated with Hal,, or or Oh, and contains One, two, or three heteroatoms or identical dif Ned Three n fferent Ways operation such as Nitrogen, oxygen and sulphur represents alkyl; C1 - Hal F, 6;CL, Br or I; and where the indole Ring can also be replaced by a unit of isatina; and Salts and solvates of these compounds that are acceptable from the Physiological Point of view, for the preparation of a Medicament for the treatment of Obesity, the subtypes of Nsiedad,The subtypes of Schizophrenia and Dementia of different Origins and for the Supplementary treatment in the treatment with low doses of neuroleptics. These compounds are well tolerated and have, among other things, effects on the central nervous system, which have valuable pharmacological Properties.The compounds show a High affinity for the 5-ht2a receptor and 5-ht2a receptor antagonist Properties.