Processes for isolating or purifying pravastatin or a pharmacologically acceptable salt thereof and for isolating or purifying pravastatin sodium, and a composition comprising pravastatin sodium

摘要

"PROCESSES FOR THE INSULATION OR PURIFICATION OF PRAVASTATIN OR A PHARMACOLOGICALLY ACCEPTABLE SALT OF THE SAME AND FOR THE INSULATION OR PURIFICATION OF PRAVASTATIN Sodium, AND, COMPOSITION UNDERSTANDING Sodium PRAVASTATIN". A method for the isolation or purification of pravastatin or its pharmacologically acceptable salt thereof comprises, in the process of isolation or purification of pravastatin or its pharmacologically acceptable salt thereof, the step of extracting pravastatin using an organic solvent represented by the formula. (Wherein R represents an alkyl group having three or more carbons) or the step of decomposing impurities using an inorganic acid or an inorganic base, and compositions containing pravastatin sodium thus obtained.