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Compound, process for preparing same, use of a compound, pharmaceutical composition, and methods for treating pain, functional gastrointestinal disorders, and anxiety

机译:化合物,其制备方法,化合物的用途,药物组合物以及治疗疼痛,功能性胃肠道疾病和焦虑症的方法

摘要

"Compound, process for preparing same, use of a compound, pharmaceutical composition, and methods for the treatment of pain, functional gastrointestinal disorders and anxiety" The compounds of the general formula I: R 1 is selected from any of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; wherein each phenyl ring R 1 and R 2 heteroaromatic ring R 1 may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight or branched C 1 -C 6 alkyl, NO 2 CF 3 -, C 1-6 alkoxy, chlorine, fluorine, bromine and iodine. The phenyl ring and heteroaromatic ring substitutions may take place at any position in said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds, and their use in therapy, in particular in the control of pain, anxiety and functional gastrointestinal disorders.
机译:“化合物,其制备方法,化合物的用途,药物组合物以及用于治疗疼痛,功能性胃肠道疾病和焦虑症的方法”通式I:R 1的化合物选自苯基,吡啶基,噻吩基中的任何一种,呋喃基,咪唑基,吡咯基,三唑基,噻唑基和吡啶N-氧化物;其中每个苯环R 1和R 2杂芳环R 1可以任选地和独立地被1、2或3个选自直链或支链C 1 -C 6烷基,NO 2 CF 3-,C 1-6烷氧基的取代基进一步取代,氯,氟,溴和碘。苯环和杂芳族环的取代可发生在所述环系统中的任何位置;在本申请中公开并要求保护的化合物以及包含该新型化合物的盐和药物组合物,及其在治疗中的用途,特别是在控制疼痛,焦虑症和功能性胃肠疾病中。

著录项

  • 公开/公告号BR0209665A

    专利类型

  • 公开/公告日2004-04-20

    原文格式PDF

  • 申请/专利权人 ASTRAZENECA AB;

    申请/专利号BR20020209665

  • 申请日2002-05-16

  • 分类号C07D211/58;C07D401/06;C07D407/06;C07D409/06;C07D417/06;A61K31/4468;A61K31/4523;A61P25/04;A61P25/00;

  • 国家 BR

  • 入库时间 2022-08-21 23:12:09

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