Substituted 2- (3,5-bis-trifluoromethyl-phenyl) -N- 6 -, (1,1-dloxo-1-yl-6-thiomorpholin-4-yl) -4- (2-methyl or 4-fluoro-2-methyl) ) phenyl-pyridin-3-yl -n-methylisobutyramide

摘要

2- (3,5-BIS-TRIFLUOROMETIL-PHENYL) -N-16- (1,1-DIOXO-1LHI-6'-THOMORFOLIN-4-IL) -4- (2-METHYL or 4-FLUOR-2 REPLACED METHYL) PHENYL-PYRIDIN-3-IL] -N-METHYLISOBUTIRAMIDE ". The invention relates to 2- (3,5-bis-trifluoromethyl-phenyl) N- [6- (1,1-dioxo-1α] -4,6-thiomorpholin-4-yl) -4-o compounds. -tolyl-pyridin-3-yl] -N-methyl-isobutyramide and 2- (3,5-bis-trifluoromethyl-phenyl) -N- [6- (1,1-dioxo-1) thiomorpholin-4-yl) -4- (4-fluoro2-methyl-phenyl) -pyridin-3-yl] -N-methyl-isobutyramide, which may be used to treat migraine, rheumatoid arthritis, asthma, hyperactivity bronchial disease, inflammatory bowel disease or for the treatment of disorders including Parkinson's disease, anxiety, depression, pain, headache, Alzheimer's disease, multiple sclerosis, edema, allergic rhinitis, Crohn's disease, eye injury, eye inflammatory diseases, psychosis, movement nausea, induced vomiting, emesis, urinary incontinence, psychoimmunological or psychosomatic disorders, cancer, withdrawal symptoms from narcotics or nicotine, traumatic brain damage or benign prostatic hyperplasia.