Methods for treating or preventing alzheimer's disease and a disease, treating alzheimer's disease and an individual having or preventing a patient from acquiring a disease or condition, to inhibit beta-secretase activity, the cleavage of a protein isotype. amyloid precursor and the production of amyloid beta peptide in a cell and beta amyloid plaque in an animal to produce a beta-secretase complex, composition and use of a compound

摘要

"METHODS FOR TREATING OR PREVENTING ALZHEIMER MALF AND A DISEASE, TREATING ALZHEIMER MALF AND A GUY WHO HAS OR TO PREVENT A PATIENT TO ACHIEVE A DISEASE OR CONDITION TO INHIBIT BETA SECRETASE ACTIVITY, PRECURSOR PROCESS AND BETA AMYLOID PEPTIDE PRODUCTION IN ONE CELL AND BETA AMYLOID PLATE IN AN ANIMAL, TO PRODUCE A COMPLEX BETA SECRETASE, COMPOSITION AND USE OF A COMPOUND. " Methods for treating Alzheimer's disease, and other diseases and / or inhibiting beta-secretase enzyme, and / or inhibiting beta A peptide deposition in a mammal are described by the use of compounds of formula (I) wherein 1 ~, R ~ 2 ~, R ~ 3 ~ and N sym are as defined herein.