Aerosol formulations for pulmonary drug delivery to produce systemic effect

摘要

"AEROSOL FORMULATIONS FOR PULMONARY ADMINISTRATION OF MEDICINAL PRODUCTS IN ORDER TO PRODUCE SYSTEMIC EFFECT". The invention discloses an aerosol pharmaceutical composition comprising a medicament in solution in a mixture of a hydrofluoroalkane propellant and one or more co-solvents in which the aerosol liquid droplets deposited upon actuation of the inhaler have a particle size of between 0.5%. 109 m and 2.5 109 m, with an average aerodynamic mass diameter of approximately 1-2 109 m and where the fine particle fraction is at least 30%.