Aerosol formulations for pulmonary Administration of Drugs that produce a Systemic effect

摘要

Medicament comprising a solution in a mixture of: (a) hydrofluoroalkane propellant that includes one or more Selected hfas HFA and HFA 227 134; and b) one or more consolventes, as ethanol in an amount of up to 30% p / p or a derivative (Poly) selected polialcoxila alcohol alkoxylates Two (transcutol) and polialcoxilados ethers and Esters.Where, The drops of liquid spray to administer the Act the inhaler with a particle size between 0.5 and 2.5 um um with a median aerodynamic diameter in the mass of approximately 1 um to 2 um and where the fraction of Fine particles is at least 30%.Also refers to an aerosol Inhaler that contains a formulation as described is characterized in that the valve Actuator has a Hole diameter of 0.2 mm and 0.5 mm