Compound, composition, use of a compound, and methods for inhibiting telomerase in vitro or in vivo, for regulating cell proliferation in vitro or in vivo, and for treating a proliferative condition.

摘要

"COMPOUND, COMPOSITION, USE OF A COMPOUND, AND METHODS FOR INHIBITING IN VITRO OR IN VIVO TELOMERASE, FOR REGULATING IN VITRO OR IN VIVO CELL PROLIFERATION, AND FOR TREATMENT OF A PROLIFERATIVE CONDITION". This invention belongs to certain acridone and acridine compounds of Formula (1) that inhibit telomerase, regulate cell proliferation, etc. and / or treat cancer, proliferative conditions, etc .; where: (a) K is = o, L is -H, alpha single bond, beta is a double bond, gamma is a single bond (acridones); or (b) K is a 9-substituent, L is absent, alpha is a double bond, beta is a single bond, gamma is a double bond (acridines); and wherein: J 1 is a 2 or 3 substituent; R 2 is a 6 or 7 substituent; They are each a group of the formula -N (R 2 N 3) - W, wherein: R 2 N 2 is a nitrogen substituent and is hydrogen, C 1 -C 7 alkyl, C 3 -C 20 heterocyclyl or C 5 -C 20 aryl and is optionally substituted; and W is C 1 -C 7 alkyl, C 3 -C 20 heterocyclyl or C 5 -C 20 aryl and is optionally substituted; and wherein, when K is a 9-substituent, K is a group of Formula -N (R 2 N 3) - q, where: R 2 N 4 is an amino substituent and is hydrogen, C 1-1. C1-7 alkyl, C1-3 heterocyclyl or C1-5 aryl; and Q is C 1 -C 7 alkyl, C 3 -C 20 heterocyclyl or C 5 -C 20 aryl and is optionally substituted; and their pharmaceutically acceptable salts, esters, amides, solvates, hydrates and protected forms. The present invention also pertains to pharmaceutical compositions comprising such compounds and the use of such compounds and compositions, both in vitro and in vivo, to inhibit telomerase, to regulate cell proliferation, etc. and / or cancer treatment, proliferative conditions, etc.