Enhancing technique is used to prepare 3 { 2- fluoro- 1, the 2-benzisoxazol-3-yl) -1- piperidinyls of 4-(6- ethyl } -6,7,8,9- tetrahydro -2- methyl -4H- pyridos 1,2-a pyrimidin-4-ones

摘要

The purpose of the present invention is improved programs(i)Formula { 3-2-- [4--(6-3 fluoro- -1,2-- benzisoxazole piperidinyls -- yl)-- ethyl] -- 1--(6 ,7,8,9 } -- 2-- methyl -- 4h-1,2a (ii)Pirido [] pyrimidin-4-one(Risperidone)Add salt to oximnakalk/u00e1lif/u00e9m with g/u00f3gy/u00e1szatilagalkalmas savadd/u00edci/u00f3s formula -- by hydroxyl id,Alkali carbonate or alkali metal --(1-4 sz/u00e9natomosalkoxid)In v/u00e9gzettgy/u0171r/u0171z/u00e1r/u00e1sa indifferent in an organic solvent.The formula of (i) under the conditions of of is existing, wherein the report halog/u00e9natom of hal passes through a base.Atal/u00e1lm/u00e1ny is according to a general formula(xiv)Halog/u00e9nsz/u00e1rmaz/u00e9kot's(i)Formula base portion savadd/u00edci/u00f3s s/u00f3v/u00e1 alak/u00edt/u00e1savagy savadd/u00edci/u00f3s salt,One formula(v)-- piperidines,Under the conditions of it is existing for a kind of salt of oximmal vagysavadd/u00edci/u00f3s reag/u00e1ltatnak base portions,(ii),Apply the oxime of formula g/u0171r/u0171z/u00e1r/u00e1s/u00e1n/u00e1l atent solvent 1-4 sz/u00e9natomosalkanolt. ?