1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVES ALPHA1-ADRENOCEPTOR BLOCKERS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present invention relates to novel 1,4-disubstituted piperazine derivatives of the formula (I) and their pharmaceutically acceptable acid addition salts having excellent uro-selective α 1 -adrenoceptor antagonist activity. The compounds of the present invention hold promise for the treatment of the symptoms of benign prostatic hyperplasia. The present invention also relates to methods for the preparation of novel compounds, pharmaceutical compositions containing them, and methods for treating the symptoms of benign prostatic hyperplasia using compounds. In the formula (I), A is a straight or branched C1-C4 alkyl group; R is cinnamyl, benzyl or substituted benzyl, phenyl. SHE