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1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVES ALPHA1-ADRENOCEPTOR BLOCKERS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES USEFUL AS URO-SELECTIVES ALPHA1-ADRENOCEPTOR BLOCKERS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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机译:1,4取代的哌嗪衍生物用作尿液选择性α1-肾上腺素能受体阻滞剂,以及包含它们的药物成分
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摘要
The present invention relates to a novel 1,4-disubstituted piperazine derivatives of Formula I, and their pharmaceutically acceptable acid addition salts having excellent uro-selective alphaSUB1/SUB-adrenoceptor antagonistic activity exceeding those of previously described compounds. The compounds of the present invention hold promise for treating the symptoms of benign prostatic hyperplasia (BPH). The invention also relates to methods for making the novel compounds, pharmaceutical compositions containing the compounds, and method of treating the symptoms of benign prostatic hyperplasia using the compounds.
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