ARYLOXYARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF IN THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND OTHER DISEASES CHARACTERIZED BY MATRIX METALLOPROTEINASE - 13 ACTIVITY

摘要

Compounds of the formula or the pharmaceutically acceptable salts thereof, wherein R1 is (C1-C6) alkyl; R2 is (C1-C6) alkyl; or R1 and R2 taken together with the carbon atom to which they are attached form a ring selected from (C5-C7) cycloalkyl, 4-tetrahydropyranyl and 4-piperidinyl; R3 is hydrogen or (C1-C6) alkyl; and Y is a substituent on any of the carbon atoms of the phenyl ring capable of supporting an additional bond, independently selected from fluoro, chloro, trifluoromethyl, (C1-C6) alkoxy, trifluoromethoxy, difluoromethoxy and (C1-C6) alkyl. 1892 ז' באב התשס" ד - July 25, 2004