首页> 外国专利> 4-(fenýl-píperidín-4-ýlíden-metýl)-bensamíðafleiður og notkun þeirra til meðhöndlunar á sársauka, kvíða eða truflunum í maga og þörmum

4-(fenýl-píperidín-4-ýlíden-metýl)-bensamíðafleiður og notkun þeirra til meðhöndlunar á sársauka, kvíða eða truflunum í maga og þörmum

机译:4-(苯基-哌啶丁-4-亚甲基-甲基)-苯甲酰胺衍生物及其在治疗胃,肠疼痛,焦虑或疾病中的用途

摘要

Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety, and functional gastrointestinal disorders.
机译:通式I R1的化合物选自苯基,吡啶基,吡咯基,噻吩基,呋喃基,咪唑基,三唑基,噻唑基和吡啶N-氧化物中的任何一种;其中每个R 1苯环和R 1杂芳环可任选且独立地被1、2或3个选自直链和支链C1-C6烷基,NO2,CF3,C1-C6烷氧基,氯,氟,溴和碘的取代基取代。苯环和杂芳环上的取代可发生在所述环系统上的任何位置;在本申请中公开并要求保护的化合物以及包含该新型化合物的盐和药物组合物及其在治疗中的用途,特别是在疼痛,焦虑症和功能性胃肠疾病的治疗中。

著录项

  • 公开/公告号IS7024A

    专利类型

  • 公开/公告日2003-11-11

    原文格式PDF

  • 申请/专利权人 ASTRAZENECA AB;

    申请/专利号IS20030007024

  • 申请日2003-11-11

  • 分类号C07D401/06;C07D405/06;C07D409/06;C07D211/70;A61K31/445;A61K31/4523;A61P25/04;A61P25/22;

  • 国家 IS

  • 入库时间 2022-08-21 23:10:13

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