PHENOXAZINE ANALOGS USEFUL AS AMYLOID AGGREGATION INHIBITORSAND TREATMENT OF ALZHEIMER'S DISEASE AND DISORDERS RELATED TO AMYLOIDOSIS.

摘要

Disclosed are compounds of the Formula I (see formula I) wherein: R1 is hydrogen, lower alkyl, or cycloalkyl; R2 is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, aryl, heteroary l, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, or mono- or dialkylamino; and R3 and R4 independently are hydrogen, lower alkoxy, aryl, heteroaryl, haloge n, hydroxy, cyano, carboxy, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, mono- or dialkylamino, or unsubstituted or substituted lower alkyl or lower alkenyl; or R3 and R4 together form an unsubstituted or substituted carbocyclic grou p. Also provided is a method of inhibiting the aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits.