Phenoxazine analogs useful as inhibitors of amyloid aggregation and treatment of alzheimer's disease and amyloidosis-related disorders

摘要

"Useful phenoxazine analogues as inhibitors of amyloid aggregation and treatment of Alzheimer's disease and amyloidosis-related dysfunctions". Compounds of Formula I wherein: R1 is hydrogen, lower alkyl, or cycloalkyl; R 2 is hydrogen, lower alkyl, lower alkoxy, halogen, hydroxyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, aryloxyxyl, heteroarylalkoxy, cyano, carboxyl, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl or amino alkylamino; and R 3 and R 4 are independently hydrogen, lower alkoxy, aryl, heteroaryl, halogen, hydroxyl, cyano, carboxyl, alkoxycarbonyl, carbamoyl, sulfamoyl, nitro, trifluoromethyl, amino, mono- or di-alkylamino or lower alkyl or unsubstituted or substituted lower alkenyl; or R4 and R4 together form a substituted or unsubstituted carbocyclic group. Also provided is a method of inhibiting aggregation of amyloid proteins using a compound of Formula I and a method of imaging amyloid deposits.