Azerbaijani derivatives as cccr-3 receptor target country

摘要

It refers to a formula compound, wherein Ar is an optional phenyl, replaced by halide, c1-c8-tar, cyanogen or nitro, R1 is h or c1-c8-tar, and replaced by hydrogen Xi, c1-c8-tar, aciloxi, halogeno, carboxi, c1-c8-alcoxicarbon-n (R4) R5, - con (R6) R7 or monovalent cycle; R2 es h, C1-c8-tar or c3-c10-cycloquilo; R3 is c1-c8-tar, which is substituted by phenyl, phenyl, amino, formate or northwest non-n-propyl, or c3-10-cycloquilo, which can be substituted with benzo, an isomer containing 1-4 heterogeneous, phenyl or nano-n-propyl, or halogenated, cyanogen, hydrogen Xi, acolo, hydrocarbon, so2nh2, c1-c8-lo, O R2 and R3 form a 5-10 fear cycle with n;R4 and R5 are h or c1-c8-tar, or R4 is h, R5 is hydrogen xi-c1-c8-tar, ACIO, so2r8 or C n (R6) R7, or form a heterocycle of 5-6 members with N; R6 and R7 are h or c1-c8-tar, or form a heterocycle with N; R8 is c1-c8-tar, c1-c8-halogen or benzene; x-C = - C.- that is...-CH2...it is life.This is O, s, M is 1-4, N, P, Q, each o, 1. 1 - (s) - 1-tert-butox methyl-3 - [3 - (4-fluoro-phenyl-phenyl-3 - (4-fluoro-phenyl-phenyl-phenyl-phenyl-3 - [3 - [3 - (4-fluoro-phenyl-4-fluoro-phenyl-phenyl-phenyl-1-1] - [3 - (3, 4-fluoro-phenyl-phenyl-1) - 3 - (3 ----------- (4) - fluoro-phenyl-phenyl-phenyl-1 ------), fluoro-1 - (3 -), fluoro phenyl-phenyl-1 - (3 ------ urea, etc. They are useful in the treatment of CCR-3 (especially flammability or allergies).