The formulation includes 1h-quinazolina-2, 4-diona derivatives as the target country of AMPA receptor in the form of immediate release tablets and preparation

摘要

1. A pharmacological formula in the form of a plate, including: 2% to 10% by weight of each tablet of hydroxypropyl cellulose and 1 h-quinazolina-2.4-diona (I) active compounds, 5% to 27.5% by weight of each tablet, wherein R1 is CF3, chf2, ch2f, CH3CHF, etc.; R2 is Replaced by halogen, nitric acid, cyanogen, etc The most popular formula compounds (I): (I)Page: 1(III)There are others It may also include insoluble water fillers, such as microcrystalline cellulose, with a weight percentage of 25 to 50%; dissolving agents, such as starch glycerin, with a weight percentage of 2.5 to 15%; and other precursors, such as flow assistants and lubricants. This is also a preparation process. These compounds (I) have the activity of antagonizing AMPA receptor