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PEPTIDE CAPABLE OF BINDING TO INTERLEUKIN-1b-CONVEPEPTIDE CAPABLE OF BINDING TO INTERLEUKIN-1b-CONVERTING FERMENT (ICE) AND A PHARMACEUTICAL COMPOSITIRTING FERMENT (ICE) AND A PHARMACEUTICAL COMPOSITION CONTAINING IT ON CONTAINING IT
PEPTIDE CAPABLE OF BINDING TO INTERLEUKIN-1b-CONVEPEPTIDE CAPABLE OF BINDING TO INTERLEUKIN-1b-CONVERTING FERMENT (ICE) AND A PHARMACEUTICAL COMPOSITIRTING FERMENT (ICE) AND A PHARMACEUTICAL COMPOSITION CONTAINING IT ON CONTAINING IT
The present invention relates to a peptide capable of binding to ICE, which peptide consists essentially of the amino acid sequence of SEQ ID NO: 1 reported in the Sequence Listing, in which Xaa is selected between Asp and Ala, optionally containing one or more amino acids at its N-terminal and/or C-terminal end (including 19-40 amino acds). It also relates to the use of the above peptide, for the preparation of pharmaceutical compositions active in pathologies requiring ICE inhibition.
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机译:本发明涉及一种能够与ICE结合的肽,该肽基本上由序列表中报道的SEQ ID NO:1的氨基酸序列组成,其中Xaa选自Asp和Ala之间,任选地包含一个或多个氨基N末端和/或C末端的氨基酸(包括19-40个氨基ACD)。它还涉及上述肽在制备在需要ICE抑制的病理学中有活性的药物组合物中的用途。
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