Binding agent comprising at least one peptide capable of binding myostatin, a polynucleotide sequence encoding the binding agent, an expression vector comprising the polynucleotide, a host cell comprising the expression vector, a pharmaceutical composition comprising the binding agent and uses thereof, a method of detecting or measuring myostatin in a sample and a method of diagnosing a myostatin related disorder in a subject

摘要

The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therepeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and other metabolic disorders including diabetes and obesity.