A METHOD OF SEPARATING THE RACEMATE OF TRAMADOL

摘要

THE PRESENT INVENTION RELATES TO A METHOD OF SEPARATING THE RACEMATE OF TRAMADOL, WHICH IS CHARACTERISED IN THAT A RACEMIC TRAMADOL SALT IS CONVERTED INTO THE BASE, THE (-)-ENANTIOMER OF TRAMADOL IS SEPARATED BY PRECIPITATION WITH L-(+)- TATARIC ACID, AND THE (+) ENANTIOMER OF TRAMADOL IS ISOLATED FROM THE MOTHER LIQUOR FROM TARTARIC ACID PRECIPITATION BY RELEASING THE TRAMADOL BASE AND SUBSEQUENT CONVERSION INTO A SALT WHICH IS DIFFERENT FROM TARTRATE.