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METHOD FOR COMBINATIONAL REACTION FINDING FOR THE PRODUCTION OF USEFUL PRODUCTS

机译:生产有用产品的组合反应发现方法

摘要

The invention relates to a method for the algorithmic search for and production of biologically active chemical compounds. Said method comprises the following steps: (1) producing an algorithmic library of different multicomponent reactions; starting from a library of suitable and diverse types of chemical starting compounds; (2) biologically testing said library; (3) identifying suitable multicomponent reactions from this range of suitable reactions; (4) choosing a multitude of chemical starting substances of those types that are required for the identified and suitable multicomponent reactions; (5) finding optimum combinations from said constructed chemical range of suitable multicomponent reactions by (6) algorithmically producing and biologically testing compounds of said library. The inventive method is exemplified by way of the example of finding new antibiotically active polyketoidous compounds.
机译:本发明涉及用于算法搜索和生产生物活性化合物的方法。所述方法包括以下步骤:(1)产生不同多组分反应的算法库;从合适的和不同类型的化学起始化合物的库开始; (2)对所述库进行生物学测试; (3)从该合适反应范围中确定合适的多组分反应; (4)选择确定和合适的多组分反应所需的多种化学起始物质; (5)通过(6)通过算法产生和生物学测试所述文库的化合物,从所述构建的合适的多组分反应的化学范围中找到最佳组合。通过发现新的具有抗生素活性的多酮类化合物的例子来举例说明本发明的方法。

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