DERIVATIVES OF CONDENSED IMIDAZOLS AS MODULATORS OF RESISTANCE TO MULTIPLE DRUGS.

摘要

THIS INVENTION REFERS TO THE FORMULA COMPOUNDS (I), THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY ISOMERIC FORMS, IN WHICH THE LINE STITCHED IN AN OPTIONAL LINK; N ES 1 O 2; R1 IS HYDROGEN, HALOGEN, FORMULO, RENT C1 - C4 OPTIONALLY REPLACED WITH HYDROXY, OXIALQUIL C1-C4, OXIALQUIL C1-C4 CARBONYL, IMIDAZOLYL, TIAZOLYL OR OXAZOLYL OR A RADICAL-RX-R7 -COR10 IN WHICH -X- IS A DIRECT LINK, C1-C4 CANDYL OR C2-C6 RENT; R5 IS HYDROGEN, C1-C12 RENT, AR, HET, C1-C6 RENT REPLACED WITH C1-C4 OXIALQUIL, ARYL OR HETEROARILE; R6 AND R7 ARE EACH OF THEM INDEPENDENTLY HYDROGEN OR C1-C4 RENT; R2 IS HYDROGEN, HALOGEN, RENT C1-C 4, HYDROXIAL alkyl C1-C4, ALCOXI C1-C 4 CARBONYL, CARBOXYL, FORMIL OR PHENYL; R3 IS HYDROGEN, C1-C4 RENT OR OXIALQ C1-C4 UIL; R4 IS HYDROGEN, HALOGEN, C1-C 4 RENT, C1-C4 OXIALQUIL OR C1-C4 UILO HALOALQ; Z ES -CH2-, -CH2 - CH2 -, -CH = CH-, CHOH-CH2 -, -O-CH2 -, -C (= O) -CH2 O -C (= NOH) CH2 -; A-B IS A BIVALENT RADICAL; A 1 IS A DIRECT LINK, OPTIONALLY REPLACED C1-C6 CANDYL, C1-C6-OXI-C1-C6 CANDYL 6, CARBONYL, C1-C6 CARBONYL, C1-C6 OPTIONALLY OXIALCANDYL SUBSTITUTE; A 2 IS A DIRECT LINK OR C1-C6 CANDYL; AND Q IS ARILO. PROCEDURES ARE DESCRIBED FOR THE PREPARATION OF SUCH PRODUCTS, FORMULATIONS THAT INCLUDE THESE PRODUCTS AND THEIR USE AS A MEDICINAL PRODUCT, IN PARTICULAR TO INHIBIT REVERTIRLOS EFFECTS OF MULTIPHARMACO RESISTANCE.