DERIVATIVES OF PIPERAZIN-2,5-DIONA AS MODULATORS OF RESISTANCE TO MULTIPLE DRUGS.

摘要

A PIPERAZINDIONA OF GENERAL FORMULA (I) WHERE R 1 IS HYDROGEN; ONE FORMULA GROUP - COR {SUP, 3} - (NH) {SUB, T} COR {SUP, 3} WHERE T IS 0 OR 1 YR {SUP, 3} IS SELECTED FROM (I): (A) WHERE V EN 0 OR 1 WHEN T IS 1 AND V IS 1 WHEN T IS 0; AND WHERE N IS 0, 1, 2 OR 3 AT LEAST ONE OF N AND M IS DIFFERENT FROM 0; E (II): (B) WHERE P IS 1 OR 2 YZ IS CQUARETTE C {SUB, 2} - C {SUB, 6} OR A PHENYLL GROUP OPTIONALLY REPLACED BY ALCOXI C {SUB, 1} C {SUB, 6} ; E (III): (C) WHERE R {SUP, 9} IS RENT C {SUB, 1} C {SUB, 6} ;, PYRIMIDINYL OR A PHENYLL GROUP OPTIONALLY REPLACED BY ALCOXI C {SUB, 1} - C {SUB , 6}; AND (F) YR {SUP, 2} IS HYDROGEN OR A FORMULA GROUP - COR {SUP, 3} AS IT HAS ALREADY BEEN DEFINED, ALWAYS THAT ONE OF R {SUP, 1} YR {SUP, 2} BE HYDROGEN AND THE ANOTHER IS NOT HYDROGEN; AND THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME, WITH ACTIVITY AS MODULATORS OF PHARMACOS RESISTANCE.