INHIBITION OF THE ADHERENCE OF THE LYMPHOCYTES TO THE VASCULAR ENDOTHELIUM THROUGH A NEW INTERACTION RECEIVING EXTRACELLULAR-BINDING MATRIX.

摘要

THE INVENTION REFERS TO A METHOD FOR INHIBITING THE ADHESION OF A CELL TO ANOTHER WHICH LEADS TO THE INTERFERENCE OF THE INTERACTION BETWEEN THE EXTRACELLULAR MATRIX RECEIVER AND ITS BINDING. THE INVENTION IS BASED ON THE DISCOVERY THAT THE ALFALIBET EXTRACELLULAR MATRIX RECEIVER 1 PROMOTES THE ADHESION OF THE LYMPHOCYTES TO THE ENDOTELIAL CELLS THROUGH THE UNION TO A DEFINED PEPTIDE SEQUENCE. BEFORE THIS INVENTION, THE LEGEND OF THE ALFA4BETA1 RECEIVER HAD NOT BEEN IDENTIFIED, OR THE FUNCTION OF THE ALFALIBET 1 RECEIVER AT THE UNION OF THE LYMPHOCYTES IS KNOWN. BY PREVENTING INTERACTION BETWEEN ALFALIBETA 1 RECEIVER AND ITS LIGENDS USING ANTIBODIES OR PERMITTED SEQUENCES DEFINED, THE PRESENT INVENTION ALLOWS, FOR THE FIRST TIME, SPECIFIC INTERVENTION IN THE MIGRATION OF LYMPHOCYTES THROUGH THE ENDORIUM. THEREFORE, THE PRESENT INVENTION HAS A PARTICULAR CLINICAL UTILITY IN THE SUPPRESSION OF THE IMMUNE RESPONSE; IN VARIOUS SPECIFIC PLACES OF THE INVENTION, THE ADHERENCE OF THE LYMPHOCYTES TO THE ENDOTHELIUM CAN BE SYSTEMATICALLY INHIBITED OR MAY ALTERNATIVELY BE LOCATED TO PARTICULAR FABRICS OR CIRCUMSCRIBED AREAS. ACCORDING TO THIS, THE INVENTION PROVIDES MEANS FOR THE TREATMENT OF DISEASES THAT HAVE TO DO WITH AUTOIMMUNE RESPONSES AS WELL AS WITH OTHER CHRONIC OR RECURRING ACTIVITIES OF THE IMMUNE SYSTEM, INCLUDING ALLERGY, ASTHMA, AND CHRONIC INFLAMMATION CONDITIONS OF THE.