USE OF GLP-2 AGONISTS TO IMPROVE THE FUNCTIONING OF THE SUPERIOR GASTROINTESTINAL TRACT.

摘要

The invention relates to glucagon-related peptides and their use for the prevention or treatment of diseases that affect the upper gastrointestinal tract including the esophagus and stomach. In particular, it has recently been shown that GLP-2 and GLP-2 peptide agonists can cause proliferation of tissues of the upper gastrointestinal tract. In this way the invention provides methods of proliferation of the upper gastrointestinal tract in a subject in which it is necessary. In addition, the methods of the invention are useful for the treatment or prevention of inflammatory conditions of the upper gastrointestinal tract, including inflammatory diseases. GLP-2 stimulates the growth of upper gastrointestinal tissue when administered in conjunction with other peptide hormones. The invention also provides pharmaceutical compositions of GLP-2 with at least one other peptide hormone, methods for improving the growth of upper gastrointestinal tissue and gastrointestinal diseases by increasing serum levels of GLP-2 and at least one other peptide hormone. equipment for carrying out the processes of the invention.