Recombinant fusion proteins based ribosome inactivating proteins of mistletoe Viscum album.

摘要

Nucleic acid molecule, which encodes a fusion protein which has the following components: (a) an effector module which exerts its cytotoxic action intracellularly; (B) a processing module which is covalently linked to the effector module and which has a recognition sequence for a protease, wherein the processing module comprises the propeptide mistletoe lectin or a fragment or derivative thereof, wherein the fragment or derivative has a recognition sequence for a protease and intracellular release of the effector module in the target cells by the own proteases cells during endocytosis receptor may occur in endosomes and prelisosomas induced, and wherein the propeptide mistletoe lectin is encoded by a nucleic acid molecule.