USE OF PHARMACEUTICAL COMPOUNDS IN THE TREATMENT OF SYMPTOMS OF DISORDERS RELATED TO NEUROLOGICAL DISEASES AND ETIOLOGICALLY RELATED SYMPTOMOLOGY

摘要

The invention regards a novel use of pharmaceutical compositions in treatingsymptoms of disorders relating to neurological diseases and for treatingpathophysiologicially related symptomology in other body tissues, includingperipheralneuropathies, secondary symptomology of diabetes, Alzeheimer's disease,Parkinson'sdisease, alcoholic polyneuropathy and age-onset symptomology. Covalent bondcrosslinking of protein and lipid subcellular elements appears to underlie theformation ofpolymerized aggregates of neurofilaments, other structural proteins andlipofuscin. Theuse of certain compounds may compete with cellular protein and lipid aminegroups forreaction with disease-induced carbonyl-containing aliphatic and aromatichydrocarbons.Such derivatized pharmacological agents can then be excreted by the kidneys,thusremoving the toxic agent(s). The presence of an acid functional group on theagent usedfacilitates kidney recognition and removal. Another application of the presentinventionincludes the oral use of non-absorbable polyamine agents such as chitosan tocovalentlybind and sequester potentially toxic carbonyl compound present in the diet.Veterinary,food processing and cosmetic applications of the present invention are alsodescribed.