PROCESS OF SCREENING PLASMA SAMPLES FOR EFFECTIVE ANTIBODY TITERS AGAINST RESPIRATORY VIRUSES

摘要

A process for identifying plasma samples containing effective antibody titersfor the treatment and/or prophylaxis of in-fections caused by a respiratory virus. The process comprises contacting aplasma sample containing antibodies against a respira-tory virus with the respiratory virus. The mixture of plasma sample and virusis then contacted with a plurality of cells. The re-maining non-neutralized virus in the sample is then determined through animmunoassay following replication of the virus in thecells. Plasma samples which, at a preselected minimum antibody titer value,prevent viral replication in the cells, are then select-ed. Plasma from which the selected samples were derived are then pooled toprovide an immunoglobulin preparation having in-creased effectiveness in the prophylaxis and/or treatment of infections causedby the respiratory virus.