.ALPHA.(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND .ALPHA.(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM

摘要

The invention relates to the genetic manipulation of non-human animals. Moreparticularly, the invention relates to genetic manipulation of non-humananimals to be used for xenotransplantation. The invention provides a method ofselecting GGTA l null cells, a viable GGTA l null swine, methods for makingsuch swine, and methods of using cells, tissues and organs of such swine forxenotransplantation.