Endobronchial delivery of antibiotic in individuals with impaired lung tissue or lung function

摘要

Methods for producing a significant anti-P. aeruginosa effect in a cystic fibrosis patient 6 years of age or younger that presents with early P. aeruginosa infection are disclosed. Such methods involve endobronchial administration of an aerosolized tobramycin formulation, wherein said formulation is administered as a monotherapy for a period of about one month. In addition, methods for selecting a cystic fibrosis patient 6 years of age or younger that my benefit from the claimed methods, as well as methods for monitoring anti- P. aeruginosa aerosol antibiotic treatment outcome in such patients, are disclosed.