Tropism-modified adenoviral vectors, preferably for targeting b-lymphocytes or ovarian cells

摘要

The present invention relates to recombinant adenoviruses, the tropism has been modified in order to allow it to infect lymphocytes. it also relates to methods for the preparation of such as adenoviruses, as well as their uses, especially for the transfer of nucleic acids in the b lymphocytes in vitro, ex vivo or in vivo, in an experimental, industrial or therapeutic vaccine. The present invention more specifically describes the modification of the gene of the fiber of the adenovirus for the purpose of the target the b lymphocytes, as well as other modifications and / or constructs which make it possible to confer to a specific character for these cells. The present invention is characterized in particular by the introduction into the fiber of the sequence of a targeting peptide recognizing the receiver cd21 expressed on the surface of the lymphocytes b / p