Tripartite motif protein 32 activation promotes carcinogenesis by blocking certain stress-induced apoptotic signaling pathways, while inactivation of tripartite motif protein 32 signaling exacerbates apoptotic signaling in muscle dystrophy. In addition, tripartite motif protein 32 interacts binds and ubiquitylates protein inhibitors of activated signal transducer and activator of transcription (PIAS) to promote PIAS degradation. This interaction of tripartite motif protein 32 with PIAS provides a mechanism to alter apoptosis responses for the treatment of various disorders. Methods of modulating apoptosis, for example increasing or decreasing apoptosis, are provided. Also disclosed are methods of screening for agents that modulate apoptosis.
展开▼
