NEW VARIANTS DERIVED FROM INTERFERONS OF TYPE I, PRODUCTION PROCESS THEREOF AND THEIR APPLICATIONS

摘要

PCT No. PCT/FR91/00953 Sec. 371 Date Sep. 11, 1992 Sec. 102(e) Date Sep. 11, 1992 PCT Filed Nov. 29, 1991 PCT Pub. No. WO92/09691 PCT Pub. Date Jun. 11, 1992.Variants of type I interferons containing peptide extensions, and their production using recombinant DNA techniques, are described. Expression cassettes comprising DNA coding for the variant interferon, DNA coding for a signal peptide, and a promoter are described for use in transforming yeast and in the production of the variant interferons.