A carpal tunnel splint for being custom-fitted to a hand and wrist to be supported, and comprising an elongate, narrow flexible inner cushion layer for being placed on and conformed to the shape of the hand and wrist, an initially flexible intermediate layer overlying the inner cushion layer and an intermediate layer comprised of a fabric impregnated with a moisture-curable resin which hardens upon curing to form a rigid structure of the fabric which retains a shape into which it is molded during curing, thereby also holding the flexible inner cushion layer in a conforming shape against the hand and wrist. A flexible protective outer layer overlies the intermediate layer and is attached to the inner cushion layer for enclosing the intermediate layer and forming the inner layer, intermediate layer and outer layer into a single, integrated elongated, narrow splint structure.
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