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CASPASE-9:BIR3 DOMAIN OF XIAP COMPLEXES AND METHODS OF USE
CASPASE-9:BIR3 DOMAIN OF XIAP COMPLEXES AND METHODS OF USE
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机译:XIAP复合体的CASPASE-9:BIR3域和使用方法
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摘要
The present invention provides polypeptides and specific binding agents that modify the activity of an initiator caspase involved in apoptosis, caspase-9. The polypeptides include the third baculoviral IAP repeat (BIR3) of an IAP and form a heterodimer complex with caspase-9. Nucleic acid molecules including expression vectors encoding the polypeptides and variants thereof as well as variants of caspase-9 are provided. Such polypeptide and nucleic acid molecules may be used for modifying apoptosis.
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