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POST-COATED LIPOSOME/LIPOPLEX FOR TARGETED DRUG/GENE DELIVERY AND LIPID LINKED TO A DELIVERY, TARGETING OR STABILISING MOIETY
POST-COATED LIPOSOME/LIPOPLEX FOR TARGETED DRUG/GENE DELIVERY AND LIPID LINKED TO A DELIVERY, TARGETING OR STABILISING MOIETY
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机译:用于目标药物/基因递送的脂质后脂质体/脂质体,以及与递送,目标或稳定部分相关的脂质
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摘要
The present invention provides a delivery vehicle for a therapeutic agent comprising a modified lipid and a therapeutic agent; wherein the modified lipid comprises a lipid and a delivery, targeting or stabilising moiety (DTS moiety); wherein the lipid is linked to the DTS moiety via a linker which is stable in biological fluid and which is unstable in defined conditions; and wherein the DTS moiety is linked to the lipid alter formation of a complex of lipid and therapeutic agent.
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