Engineered Extracellular Vesicles with Synthetic Lipids via Membrane Fusion to Establish Efficient and Targeted Drug and Gene Delivery

摘要

These studies demonstrate the incorporation of heterologous lipids into extracellular vesicles by a membrane extrusion technique for enhancing scalability. These findings suggest the engineered vesicles can be a potential substitute to solely natural extracellular vesicles for effective gene delivery. The effectiveness of gene modulation post-endocytosis via RNA interference demonstrated that the inherent uptake characteristics of the extracellular vesicles can be retained in the engineered hybrid vesicles.